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Corn Sugar or High Fructose Corn Syrup – A Name Change Doesn’t Make it Good for You

by Dr. Stephen Gangemi on May 30, 2011

High fructose corn syrup (HFCS) is getting such a bad reputation as an unhealthy food product that the Corn Refiners Association (CRA) want to change the name to “corn sugar.” This US subsidiary product can be found in just about everything, especially processed junk foods and beverages such as soda and sports drinks. Breads, cereals, “nutrition” bars, deli meats, yogurt, soups and condiments often contain HFCS too. They say the name change is for the public’s benefit and feel they are helping us all understand what exactly is in their food and where it comes from. They even launched a website to help that “uninformed” consumer become more “informed.” Well, aren’t we so lucky to have them looking out for our best interests. Of course, they’re only going to discuss basic principles in hopes that you’ll still give their nutritional-devoid, highly refined food product a second chance. Let’s look at a few “Realities” as they call them from their site where they try to dispel those nasty myths about HFCS as if they’re comparing real unicorns to horses.

CRA: High fructose corn syrup is nearly identical in composition to table sugar — both contain approximately 50% glucose and 50% fructose. Sugar and high fructose corn syrup have the same number of calories as most carbohydrates; both have four calories per gram. Because they are nearly compositionally equivalent, the human body cannot tell the difference between high fructose corn syrup and sugar.

“Nearly identical” is an understatement. Your body actually is smart enough to tell the difference between a highly refined product from corn, containing free forms of fructose, and the fructose bound to glucose to make sucrose, from sugar cane or beets. During the processing, it is said that some of the fructose in HFCS undergoes changes that makes it not well recognized in the human Krebs Cycle for primary conversion to blood glucose in any significant quantity, and therefore cannot be used for energy (ATP) utilization. This is similar to the processing of naturally occurring “cis” fats into partially hydrogenated “trans” fats – they look the same chemically other than the kink where the double bond lies, but your body cannot metabolize trans fats very well. Instead, these refined fructose sweeteners are primarily converted into triglycerides (fat in the bloodstream) and adipose tissue (body fat). While glucose is metabolized throughout the body, fructose is only metabolized in the liver, without any notable insulin release. Insulin increases the release of leptin, a hormone that also inhibits food intake. Individuals who are genetically unable to produce leptin tend to be obese; low leptin concentrations are associated with increased hunger and gains in body fat. Additionally, the rapid metabolism of fructose in the liver and resultant drop in ATP levels have been linked with mitochondrial (energy) and endothelial (blood vessel cells) dysfunction, alterations that could predispose to obesity, diabetes, and hypertension.

CRA: High fructose corn syrup is made from corn — a natural grain product. High fructose corn syrup contains no artificial or synthetic ingredients or color additives and meets the Food and Drug Administration’s requirements for use of the term “natural.”

True to some extent, but definitely not natural – it’s highly processed.  Table sugar (sucrose) is obtained by extracting sugar cane or beets with hot water, then concentrating the extract into a syrup from which solid sucrose can be crystallized. HFCS, on the other hand, goes through this process:

Step 1: Cornstarch is treated with alpha-amylase (an enzyme) to produce shorter chains of sugars called oligosaccharides.

Step 2: The mold species Aspergillus then breaks the sugar chains down even further to yield the simple sugar glucose.

Step 3: Xylose isomerase (another enzyme) converts glucose to a mixture of about 42% fructose and 50–52% glucose with some other sugars mixed in.

Step 4+: This 42–43% fructose glucose mixture is then subjected to a liquid chromatography step, where the fructose is enriched to about 90%. The 90% fructose is then back-blended with 42% fructose to achieve a 55% fructose final product. Numerous filtration, ion-exchange and evaporation steps are also part of the overall process.

What about the findings of mercury in HFCS? According to two U.S. studies, almost half of tested samples of commercial HFCS contained mercury, which was also found in nearly a third of 55 popular brand-name food and beverage products where HFCS is the first or second-highest labeled ingredient. A compound known as caustic soda, which is used to separate the corn starch from the kernel, can be tainted with mercury, and there’s no way to know whether the caustic soda used was contaminated.

CRA: Contrary to its name, high fructose corn syrup is not high in fructose. In fact, the composition of high fructose corn syrup is essentially “half fructose corn syrup” which is similar to sugar. Sugar is composed of 50% fructose and 50% glucose and high fructose corn syrup has either 42 % or 55% fructose, with the remaining sugars being primarily glucose.

This is true due to the processing step as noted above. What the corn manufactures don’t realize (or more accurately don’t want you to realize) is that the processing and refining of such a product is not identical to one that has not gone through such a process, even if the end result is the same. The most widely used varieties of high-fructose corn syrup are HFCS 55 (mostly used in soft drinks), and HFCS 42 (used in many foods and baked goods). HFCS 90, the third type of HFCS produced, is used primarily to blend with HFCS 42 to make HFCS 55.

The Corn Refiners Association further go on to state, “It is important that consumers recognize added sugars in the diet. Despite its confusing name, high fructose corn syrup is simply corn sugar – or an added sugar in the diet. It is not high in fructose as its name would suggest. High fructose corn syrup is composed of the same two simple sugars (fructose and glucose) as table sugar, honey and maple syrup.”

I don’t think it’s confusing and it is definitely not the same as honey or maple syrup just because it has the same two simple sugars in them. This statement is ridiculous. Egg protein and milk protein share a very similar amino acid profile, but they’re entirely different foods. Maple syrup is actually 95% sucrose, and although most honey has a similar concentration of fructose and glucose as HFCS depending on where the bees gathered the nectar, it is entirely different. Bees make honey through a natural process using nectar and enzymes from the honey bee itself, that’s all there is to it other than a lot of time. Honey contains nutrients and antioxidants and is more compatible to human consumption than pure fructose or HFCS. Honey also has anti-inflammatory and antimicrobial effects and it doesn’t lower salivary pH levels like other carbohydrates, especially refined sugars. I have personally never seen a patient perform poorly on honey, (unless they were allergic, of course), and have yet to see a patient do well on pure fructose or  HFCS during office testing procedures. I almost always see significant health improvements when a patient switches to honey and gets rid of HFCS and most of the fructose and sucrose in their diet. In respect to bees, they don’t perform as well on a HFCS diet, and when HFCS is heated, especially above 120 degrees Fahrenheit, it forms hydroxymethylfurfural (HMF), a chemical that can kill honey bees. This is similar to the way in which browning or frying carbohydrates produces acrylamides, a cancer-causing chemical that’s also found in many foods.

CRA: There is no scientific evidence to suggest that high fructose corn syrup is uniquely responsible for people becoming obese. Obesity results from an imbalance of calories consumed and calories burned.

Actually, it’s more than just “Calories In = Calories Out” as I discuss in this post. There can be no debate about the fact that both white sugar and HFCS, with their empty and addictive calories, are bad for you. But the real question is whether HFCS is actually worse for you—more depleting and more damaging— than ordinary sugar. Some studies that have compared HFCS to sucrose and found that they have essentially identical physiological effects. For instance, Melanson et al (2006), studied the effects of HFCS and sucrose sweetened drinks on blood glucose, insulin, leptin, and ghrelin levels. (Ghrelin is a hormone produced in the stomach and pancreas that stimulates hunger.) They found no significant differences in any of these parameters. (They were found to be equally problematic.)

In June 2010, the Journal of Hepatology suggested a link between consumption of high-fructose corn syrup in sodas and fatty liver disease. A small study published in The Journal of Nutrition suggested that fructose may make people fatter by bypassing the body’s regulation of sugars, which means it gets more quickly converted to fat than do other sugars.

Fructose has been hypothesized to cause insulin resistance, obesity, and elevated LDL cholesterol and triglycerides, leading to metabolic syndrome. One study concluded that fructose “produced significantly higher fasting plasma triglyceride values than did the glucose diet in men”.

Fructose also chelates minerals in the blood. This effect is especially important with micronutrients such as magnesium, copper, chromium and zinc. Since these solutes are normally present in small quantities, chelation of small numbers may lead to deficiency diseases, immune system impairment and even insulin resistance, a component of type II diabetes.

Ultimately it doesn’t matter what you call it – corn sugar or high fructose corn syrup or half-fructose syrup – they’re all the same. Is it much worse for you than refined white table sugar? I believe so due to how it’s processed and metabolized differently in the body. HFCS, despite that the moms in the commercial funded by the CRA advise, “high fructose corn syrup in moderation,” should be eliminated from all diets while white sugar should be limited to a certain degree, depending on an individual’s health and how their body processes sugar. Pure fruit juice should be limited too, due to its high fructose content, and it’s always a good idea to water it down if it’s very concentrated. Sugars can be very beneficial at certain times, especially during strenuous activity. Sports drinks and carbohydrate solutions containing a two-to-one ratio of glucose to fructose can increase performance and recovery in athletes. Unfortunately though, many people drink these throughout the day when they’re not even exercising rather than using pure water. Most bottled sports drinks on the American market are sweetened with HFCS, containing glucose and fructose in a closer one-to-one ratio.

How about agave? Stay far away from it. Agave “nectar” is not made from the sap of the yucca or agave plant but from the starch of the giant pineapple-like, root bulb. The principal constituent of the agave root is starch, similar to the starch in corn, and a complex carbohydrate called inulin, which is made up of chains of fructose molecules. The process by which agave glucose and inulin are converted into “nectar” is similar to the process by which corn starch is converted into HFCS. The agave starch is subject to an enzymatic and chemical process that converts the starch into a fructose-rich syrup—anywhere from 70 to 90 percent fructose. That’s right, the refined fructose in agave nectar is much more concentrated than the fructose in HFCS. It’s one of the biggest health food misconceptions currently on the market.

What’s the best sweetener? I say honey. Maple syrup is also okay too for most people and some tolerate molasses well, but it depends on the processing. Your honey should be local and raw and come from a hive that hasn’t been treated with any pesticides or other chemicals. The darker your honey, the more nutrients it contains. Next year I’ll be eating honey from my own three hives as shown in the photos below. That’s nectar in the cells of the left photo. Soon the bees will cap it off with a little bit of wax as is shown in the right photo (white parts on the outside of the frame) which will soon be honey. The yellow & brown stuff in the other cells of the right photo is pollen. You can’t get any more natural than this as a sweetener, other than pure fruit, which is also fine to some extent. Keep your fruit intake to no more than two to three servings/pieces per day as it is still a high carbohydrate food containing mostly simple sugars glucose and fructose – yeah, just like HFCS, but not quite.


I'm a board certified chiropractic physician and clinical nutritionist with a passion for true natural health care. I implement dietary & nutritional therapies, exercise & movement practices, and lifestyle changes along with manual therapy techniques to help the body heal and prevent illness and injuries.


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  1. Robin permalink

    My daughter who has ADHD is HIGHLY sensitive to high fructose corn syrup. It sends her right through the roof. It makes her much more hyperactive and highly agitated and also increases her OCD symptoms. It literally seems to alter her brain chemistry. We avoid it like the plague!
    Thanks for this post, Dr. G!

  2. Vlad permalink

    Great article. Wondering about ice cream? Any healthy varieties you know of? I found a few coconut based ones but they all use agave. Haven’t found any sweetened with honey yet.

    • Thanks. I haven’t seen any honey sweetened ones either. We use Rapadura sugar when we make our own – which looks like brown sugar, very minimally processed. Yes, a lot of the coconut ones use agave unfortunately.

  3. Vin permalink

    Is there a link between the use of HFCS in the US and obesity that can be proven? I am 45 yrs old. When I was in grade school there was usually 1 obese kid in each class of about 30. “the fat kid” was a common term and everyone knew who you were talking about. Nowadays if you say “the fat kid” you are talking about 90% of the kids. The worst part of the HFCS issue is that it is in everything, even the things that are so called “good for you”. What can be done to get HFCS outlawed and out of our food supply? Isn’t cane sugar a profitable crop? It must cost more to convert corn into a fake sugar than it costs to grow the real thing.

    • I don’t know about profits, but corn (like soy), is a government subsidized crop so you’re going to see it in everything. In regards to the link between HFCS and obesity, I’d say there is plenty of evidence pointing to total sugar consumption and obesity but it’s a little bit unclear with the HFCS. Seems like more are concerned with doing studies comparing HFCS to regular sugar, which I think is irrelevant. But if you have a huge group like the CRA along with the government behind the studies, they’d rather compare then try and find problems with their own product.

  4. Dianna permalink

    Why isn’t anyone making an ad reply to the TV ad that “Sugar is Sugar- and your body cannot tell the difference”???
    I’ve not seen any TV ads telling that the difference is what they do to the corn syrup to make it not known by the body and the link to obesity because of it being in everything as a preservative.

  5. Dianna permalink

    My comment on the ice cream is Breyer’s Natural makes some ice cream with sugar and others with sugar and HFCS. I have become lactose intolerant (as well as Gluten intolerant) and purchase “SO DELICIOUS” brand of Cultured Coconut Milk (yogurt) and their Coconut Milk Ice Cream. They do not use cows milk since it’s all coconut milk and really good! The sweetener is “organic evaporated cane juice”. Dairy Free and Soy Free. Soy is not a good thing, either. Google and read what they do to grains, including soy, to process them. I would be interested in any coconut milk products made with honey if anyone knows of them?

    • Breyers uses HFCS? If that’s true, it’s new. They never used to. Some of the SO Delicious products have agave sweetener in them.

  6. Emily permalink

    Just found your site and completely agree about HFCS. But be sure to buy local honey!

    • Yes, which is unfortunately always in short supply/high demand. I’ll be getting mine next spring from my three hives.

  7. Michelle permalink

    What’s your opinion on Coconut Sugar? From what I’ve read it’s got some good things going for it – low GI of 35, high mineral content – or is this all hype too?

    • Hi Michelle, I’d say it’s find in moderation as is even a little bit of raw sugar. It depends on your tolerance. I don’t follow the glycemic index too closely anymore because there are plenty of foods loaded with fructose that have a low GI, and are therefore not healthy. In general, the GI is very misleading. Low does not equal healthy. Coconut flour is great to use too.

  8. Signa permalink

    I would love it if you’d provide links to, or reference source information on the studies you cite. I’ve avoided HFCS for many years and have recommended the same to the people I know, but it’s always nice to have studies to cite when I’m writing about stuff like this.

    Thank you for a great website — I just found it today and am thrilled at finding such a rich resource of information on so many subjects that I’m passionate about.

    • Thanks, but honestly that probably won’t happen. Writing the articles/posts often takes a significant amount of time – which is why you don’t see daily or even weekly updates – depending on my schedule. A post like this one took several hours to comprise the information, verify its accuracy, write, edit, and post. Several meaning 5-7 hours typically I think this one was actually close to 8 hours. Adding in “research” would add on even more. Plus, a lot of what I write about is clinical observations, experience, and stuff that hasn’t been fully “studied.”

      Glad you like that site!

  9. Jessica Lee Daley permalink

    Just stumbled onto your website while researching carb-sensitivity/intolerance, and I’m greatly enjoying your articles! I’ve been quite fascinated with HFCS since o-chem; and regularly feel like I’m waging a battle as I try to raise a small child on an unprocessed-food diet. Your post like another “hoorah!” to encourage me to keep pressing on.

    I also really enjoyed Dr. Robert Lustig’s 2009 lecture on fructose.

  10. Charles Brown permalink

    Thank you for the information on agave. I first saw this product in the health food store, with all the soy items which they sell even today.

  11. Tao permalink

    What do you know about stevia?

  12. Ann permalink

    Dr. Gangemi, i am a 19 year old college student that’s very low on cash. My family have a history of stroke, diabetes, hearts disease and all the related complications that comes with it. I try my best to read about these things and share with my friends and family, although it is very discouraging because it’s hard to avoid those things. I stop eating meat because of heard of Tyson. i try to buy more organic product with the USDA approved stamp on it. But recently i started suspecting that some of those product might not be organic. Most organic product are too expansive for my income. Vegetables and soy are good for people. So now think that there is no such thing as healthy food in America! I’m trap. Any advice?

    • Still plenty of cheap ways to eat healthy, – veges, fruit, eggs.
      Soy should not be in your diet.

  13. Kevin Singel permalink

    If I consume something with a lot of HFCS in it (like US made sodas or many ice creams) I get a congested, flem loaded back of throat reaction. My wife says the gag reflex this inspires makes me sound like a dying cat! So this will happen for example if I drink a Coke but not a Mexican Coke with cane sugar in it instead of HFCS. Any comment on this physical reaction? (It sure has taught me to avoid HFCS!)

  14. Julia S permalink

    Dear Dr. Gandgemi, could you please tell me your opinion on Stevia? What if it is in the form of “organic Stevia leaf extract” does it make it better? All I can find is good infomation about stevia, but I am assuming that since the product is relatively new not enough research is done on it. Thank you very much, I’ve been following your website for a while and I really trust your opinion. Julia.

    • I think it’s okay to consume once in a while, but it should not be used daily as many do. It’s refined, and concentrated – so although “natural” it’s really not healthy. So although I personally never use stevia, I wouldn’t avoid it like I would agave or the obvious HFCS.

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